I am, of course, no expert on ballistics....and therefore cannot argue scientifically about 1 caliber vs another, or one bullet style vs another. Bullets are funny things when they hit flesh & bone. I've seen entry wounds with exit wound in places I never thought they'd be....I've seen men hit with multiple rounds and keep going (whether on adrenaline, drugs, or whatever).
I always smile when I see YouTube tests with ballistic gelatin and folks proffering why 1 round does better than another....the unfortunate thing with gelatin is that it doesn't move...If you are shooting at a live target, it may possibly move...even a fraction of an inch...in one direction or another, which may alter the bullets entry/exit trajectory...stationary gelatin not so much.
I love seeing newer bullet styles and types. saw one a while back that was all copper....RIP bullets - Radically Invasive Projectile...wicked/nasty looking little sucker. Not sure how it is ballistically...but an interesting evolution in bullet design for sure.
I guess for me, the key is....what size, weight, style bullet can you accurately put on target multiple times quickly given your limitations (if any)....oh, and I like BIG holes and a good solid THUMP for recoil (at least til I get a bit older, LOL).